AgSbF<sub>6</sub> Catalyzed Reduction of Nitroarenes by Phenylsilane to Anilines
AgSbF<sub>6</sub>-catalyzed activation of phenylsilane (PhSiH<sub>3</sub>) enables the efficient reduction of nitroarenes to produce the corresponding anilines. This methodology operates under additive-free conditions, making it highly efficient, scalable, and compatible with a wide range of electronically diverse nitroarenes. The utility of this method is exemplified by employing a cheap, commercially available metal catalyst for the facile synthesis of various anilines. Furthermore, the methodology has been extended to the synthesis of intermediates for drug molecules, demonstrating its broad applicability.
Authors
- Vadapalli Chandrasekhar (ORCID: https://orcid.org/0000-0003-1968-2980)
- Gobbilla Sai Kumar (ORCID: https://orcid.org/0000-0001-8281-1613)
- Priyabrata Biswal (ORCID: https://orcid.org/0000-0002-5211-8049)
Institutions
- Tata Institute of Fundamental Research (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1021/acs.joc.4c02639
- Citations
- 5
- Primary Topic
- Nanomaterials for catalytic reactions
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Tata Institute of Fundamental Research
- Department of Science and Technology, Ministry of Science and Technology, India