Low Blood Pressure and the Effect of Empagliflozin in Acute Heart Failure: An EMPULSE Analysis
Patients admitted for AHF with low BP had a higher risk of clinical events. Empagliflozin did not lower BP more than placebo and was effective and safe irrespective of BP. Empagliflozin should be considered for the treatment of AHF patients even when presenting with low BP.
Authors
- John R. Teerlink (ORCID: https://orcid.org/0000-0001-9527-0852)
- Piotr Ponikowski (ORCID: https://orcid.org/0000-0002-3391-7064)
- Mitchell A. Psotka (ORCID: https://orcid.org/0000-0001-7571-9886)
- Francisco Vasques‐Nóvoa (ORCID: https://orcid.org/0000-0001-9701-8538)
- Mikhail Kosiborod (ORCID: https://orcid.org/0000-0002-3750-9789)
- Sean P. Collins (ORCID: https://orcid.org/0000-0002-2305-9836)
- Robert John Mentz (ORCID: https://orcid.org/0000-0002-3222-1719)
- Jasper Tromp (ORCID: https://orcid.org/0000-0001-6043-0713)
- Christiane E. Angermann (ORCID: https://orcid.org/0000-0001-7491-7637)
- Adriaan A. Voors (ORCID: https://orcid.org/0000-0002-5417-4415)
- Jan Biegus (ORCID: https://orcid.org/0000-0001-9977-7722)
- Michael E. Nassif (ORCID: https://orcid.org/0000-0002-1232-7604)
- João Pedro Ferreira (ORCID: https://orcid.org/0000-0002-2304-6138)
Institutions
- San Francisco VA Medical Center (US)
- University Medical Center Groningen (NL)
- Saint Luke's Health System (US)
- Inserm (FR)
- National University of Singapore (SG)
- University of Groningen (NL)
- University of California, San Francisco (US)
- Universidade do Porto (PT)
- Hospital de São João (PT)
- UNSW Sydney (AU)
- Wroclaw Medical University (PL)
- Clinical Research Institute (US)
- VA Tennessee Valley Healthcare System (US)
- The George Institute for Global Health (AU)
- Universitätsklinikum Würzburg (DE)
- Saint Luke's Hospital (US)
- National University Health System (SG)
- Alaska Heart and Vascular Institute (US)
- French Clinical Research Infrastructure Network (FR)
- University of Missouri–Kansas City (US)
- Université de Lorraine (FR)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1002/ejhf.3626
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Boehringer Ingelheim España