Exploring the association between Mycobacterium avium subspecies paratuberculosis infection and rheumatoid arthritis: an immunological perspective
The study findings suggest that anti-MAP antibodies are more prevalent in RA patients compared to healthy controls, potentially implicating MAP in the development of RA. The strong immunological response to the antigen IRF5<sub>424-434</sub> warrants further investigation. Although the difference in antibody levels between previously diagnosed and newly diagnosed RA patients was not statistically significant, the overall higher prevalence of these antibodies in the RA cohort supports the hypothesis of MAP's involvement.
Authors
- Samaneh Tavasoli
- Hadi Razavi Nikoo (ORCID: https://orcid.org/0000-0001-6028-7208)
- Mehrdad Aghaei (ORCID: https://orcid.org/0000-0002-0143-7306)
- Ezzat Allah Ghaemi (ORCID: https://orcid.org/0000-0001-7727-7452)
- Negar Asgari (ORCID: https://orcid.org/0000-0002-0595-1089)
- Samin Zamani
Institutions
- Golestan University (IR)
- Golestan University of Medical Sciences (IR)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s13075-025-03501-2
- Citations
- 2
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Golestan University of Medical Sciences