Radiation-induced changes in salivary metabolite profile and pathways in head and neck cancer patients
Salivary metabolomics analysis revealed significant alterations in the metabolic profile of HNC patients undergoing RT, providing valuable insights into treatment-induced oral pathobiological changes. Alterations in salivary pathways during RT suggest disturbances in redox homeostasis, oxidative stress, and inflammation. The ability to monitor salivary metabolites and pathways non-invasively holds promise to personalized medicine in HNC treatment by enabling early detection of treatment-related toxicities, monitoring treatment response, and tailoring interventions to patient needs.
Authors
- Márcio Ajudarte Lopes (ORCID: https://orcid.org/0000-0001-6677-0065)
- Wilfredo Alejandro González‐Arriagada (ORCID: https://orcid.org/0000-0002-0563-4948)
- Arja M. Kullaa (ORCID: https://orcid.org/0000-0001-8198-8185)
- Eelis Hyvärinen (ORCID: https://orcid.org/0000-0002-8259-9533)
- Bina Kashyap (ORCID: https://orcid.org/0000-0001-9192-8645)
- Tuula Anneli Salo (ORCID: https://orcid.org/0000-0001-6039-0088)
- Sophie Ramsay
- Jopi J. W. Mikkonen (ORCID: https://orcid.org/0000-0001-8535-0875)
Institutions
- University of Helsinki (FI)
- University of Eastern Finland (FI)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Universidad de Los Andes, Chile (CL)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- Kuopio University Hospital (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Clinical Oral Investigations
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1007/s00784-025-06225-4
- Citations
- 1
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Itä-Suomen Yliopisto