Application and Prospect of CRISPR System in Alzheimer's Disease Treatment Research

Alzheimer's disease (abbreviated as AD), commonly known as senile dementia. As its name implies, it is the most common degenerative disease of the central nervous system that occurs in the elderly population. At present, there is still no effective treatment method. At present, CRISPR system-based research continues to advance in the field of AD therapy, such as CRISPR Cas9 for the construction of cell and animal models and gene knockout therapy, CRISPR Cas13 for the development of new detection technologies, CRISPRi has made progress in exploring related gene regulatory mechanisms, and CRISPRa can achieve gene transcriptional activation and functional characterization. However, these studies are still in the exploratory stage and have not yet been fully translated into effective clinical treatments. In this paper, we analyze the application of different CRISPR systems in AD treatment research, including model construction, gene editing, and exploration of regulatory mechanisms, and demonstrate their potential in AD treatment research. It provides a comprehensive reference for follow-up research, and can further optimize the technology to improve efficiency in the future, and focus on solving problems in clinical translation, so as to promote the development of AD treatment.