Triangular Causality Among Pulmonary Hypertension, Sleep Disorders, and Brain Structure at the Genetic Level: A Mendelian Randomization Study Focused on the Lung-Brain Axis
This study identifies significant causal links between PH, sleep disorders, and structural brain changes, establishing a triangular cyclic relationship that supports the lung-brain axis concept. These findings inform clinical management of PH and its comorbidities.
Authors
- Yiwei Shi (ORCID: https://orcid.org/0009-0008-7926-0871)
- Zhenxia Zhang (ORCID: https://orcid.org/0000-0001-5244-0938)
- Yukai Zhang (ORCID: https://orcid.org/0009-0002-0220-9054)
- Xuesen Su (ORCID: https://orcid.org/0000-0003-4905-6200)
- Peiyun He
- Xiaomei Kong (ORCID: https://orcid.org/0000-0003-4914-5916)
- Yangyang Wei (ORCID: https://orcid.org/0000-0002-0943-437X)
- Chenwei Zhang (ORCID: https://orcid.org/0009-0004-9485-1208)
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Nature and Science of Sleep
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/nss.s495071
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00