Colon, colorectal, and all cancer incidence increase in the young due to appendix reclassification
Reclassification of appendix NET/carcinoids as malignant has artifactually increased the incidence of colon, colorectum, and all cancer in children and adolescents and young adults. Appendix NET/carcinoids are rarely fatal in those aged younger than 40 years and should not be considered as cancer and included in colorectal cancer analyses. To the extent that the appendix artifact occurs in adults aged 40-49 years, recommendations for starting colorectal cancer screening earlier may be affected.
Authors
- Lynn A. G. Ries (ORCID: https://orcid.org/0000-0003-3754-1479)
- Stuart E. Siegel (ORCID: https://orcid.org/0000-0002-4305-1874)
- Danielle B. Cameron (ORCID: https://orcid.org/0000-0002-6146-8710)
- Archie Bleyer (ORCID: https://orcid.org/0000-0001-7738-5146)
- Sara A. Mansfield (ORCID: https://orcid.org/0000-0002-2868-0947)
- Ronald D. Barr (ORCID: https://orcid.org/0000-0002-5711-7440)
Institutions
- National Coalition for Cancer Survivorship (US)
- Nationwide Children's Hospital (US)
- Oregon Health & Science University (US)
- Massachusetts General Hospital (US)
- The University of Texas Health Science Center at Houston (US)
- McMaster University (CA)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-02-19
- DOI
- https://doi.org/10.1093/jnci/djaf038
- Citations
- 20
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 27.08