The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts
These findings hint at ET-1 involvement in ECM remodeling and early SOC stages by modulating the expression of Col1 and FN. Targeting ET-1 signaling with ET<sub>A</sub>R/ET<sub>B</sub>R antagonists might interfere with the ability of CAFs to produce key ECM proteins in this tumor.
Authors
- Valerio Licursi (ORCID: https://orcid.org/0000-0002-8172-1437)
- Danila Del Rio
- Valentina Caprara (ORCID: https://orcid.org/0000-0002-6082-7494)
- Martina Kunkl (ORCID: https://orcid.org/0000-0002-9749-1170)
- Francesca Spadaro (ORCID: https://orcid.org/0000-0002-6610-350X)
- Flavia Ottavi
- Loretta Tuosto (ORCID: https://orcid.org/0000-0001-9056-4077)
- Ilenia Masi (ORCID: https://orcid.org/0000-0001-8927-1998)
- Anna Bagnato (ORCID: https://orcid.org/0000-0002-7269-9522)
- Laura Rosanò (ORCID: https://orcid.org/0000-0002-9962-6411)
Institutions
- Istituto Superiore di Sanità (IT)
- Institute of Molecular Biology and Pathology (IT)
- Fondazione Santa Lucia (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s13046-025-03327-5
- Citations
- 5
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 8.11
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca