High ceftazidime-avibactam resistance rate in carbapenem-resistant gram-negative organisms in Pakistan’s pediatric population

Taking into account the results of this study, which depicted high resistance rates to CAZ-AVI among carbapenem resistant GNOs, and the high cost of this drug, it is suggested that a cautious selection for its use as monotherapy in sepsis and other infections should be made. It should be made mandatory to check the resistance to CAZ-AVI before its empiric use. The findings of the study also emphasize the challenges of combating new drug resistance and further research to adapt treatment strategies to the evolving antimicrobial resistance in the region.