TFF3 facilitates dormancy of anti-estrogen treated ER+ mammary carcinoma
Hence, in vivo models of anti-estrogen induced dormancy of ER+MC generated herein, identify TFF3 as a driver of this process. The combined inhibition of TFF3 and CDK4/6 may potentially alleviate the clinical challenges posed by anti-estrogen-induced dormancy in ER+MC.
Authors
- Vijay Pandey (ORCID: https://orcid.org/0000-0001-8704-0694)
- Basappa Basappa (ORCID: https://orcid.org/0000-0002-8844-468X)
- Peter E. Lobie (ORCID: https://orcid.org/0000-0002-8445-184X)
- Tao Zhu (ORCID: https://orcid.org/0000-0003-4130-1144)
- Xi Zhang (ORCID: https://orcid.org/0000-0003-4093-0897)
- Shu Chen (ORCID: https://orcid.org/0009-0006-2420-0025)
Institutions
- University of Science and Technology of China (CN)
- University of Mysore (IN)
- Shenzhen Bay Laboratory (CN)
- Tsinghua–Berkeley Shenzhen Institute (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1038/s43856-024-00710-9
- Citations
- 7
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 7.32
Funders
- National Natural Science Foundation of China
- Tsinghua University
- Shenzhen Bay Laboratory
- National Institutes of Health
- Tsinghua-Berkeley Shenzhen institute
- Tsinghua Shenzhen International Graduate School