Clinical effectiveness and safety of vedolizumab versus infliximab in biologic-naïve patients with ulcerative colitis: A comparative real-world multicentric observational study
Both VDZ and IFX are effective in biologic-naïve UC patients, however VDZ demonstrated superior endoscopic outcomes, higher treatment persistence, and a better safety profile, supporting its use as a first-line therapy.
Authors
- Omar Féres (ORCID: https://orcid.org/0000-0003-3593-0526)
- Abel Botelho Quaresma (ORCID: https://orcid.org/0000-0002-3985-7402)
- Katia da Conceição da Silva (ORCID: https://orcid.org/0009-0003-8591-1750)
- Bruno César da Silva (ORCID: https://orcid.org/0000-0001-5433-8806)
- Lígia Yukie Sassaki (ORCID: https://orcid.org/0000-0002-7319-8906)
- Antônio José Tibúrcio Alves (ORCID: https://orcid.org/0000-0002-6795-8526)
- Júlio Maria Fonseca Chebli (ORCID: https://orcid.org/0000-0003-1527-0663)
- Renata de Medeiros Dutra (ORCID: https://orcid.org/0000-0002-0060-6155)
- José Miguel Luz Parente (ORCID: https://orcid.org/0000-0003-4563-2784)
- Paulo Gustavo Kotze (ORCID: https://orcid.org/0000-0002-9632-6691)
- Munique Kurtz de Mello (ORCID: https://orcid.org/0009-0000-7728-6068)
- Rafael Luís Luporini (ORCID: https://orcid.org/0000-0003-2757-8104)
- Daniéla Oliveira Magro (ORCID: https://orcid.org/0000-0002-8180-6254)
- Rodrigo Galhardi Gasparini (ORCID: https://orcid.org/0000-0002-1032-5349)
- Juarez Roberto de Oliveira Vasconcelos
- Eron Fábio Miranda (ORCID: https://orcid.org/0000-0003-4011-5112)
- Marcello Imbrizi (ORCID: https://orcid.org/0000-0001-5397-0084)
- Luiz Ernesto de Almeida Troncon (ORCID: https://orcid.org/0000-0002-8599-2410)
- Guilherme Mattioli Nicollelli (ORCID: https://orcid.org/0000-0002-3126-2826)
- Fernando Jorge Firmino Nóbrega
- Cristiane Kibune Nagasako (ORCID: https://orcid.org/0000-0002-8403-1677)
- Sandro da Costa Ferreira (ORCID: https://orcid.org/0000-0001-7698-6599)
- Rogério Serafim Parra
- Liliana Andrade Chebli (ORCID: https://orcid.org/0000-0002-7875-1475)
Institutions
- Universidade Federal de Juiz de Fora (BR)
- Universidade de Ribeirão Preto (BR)
- Universidade Federal da Paraíba (BR)
- Pontifícia Universidade Católica do Paraná (BR)
- Universidade Federal de São Carlos (BR)
- Universidade de São Paulo (BR)
- Universidade Federal do Piauí (BR)
- Hospital Universitário Lauro Wanderley (BR)
- Universidade do Oeste de Santa Catarina (BR)
- Hospital de Clínicas Universidade Federal do Paraná (BR)
- Universidade do Vale do Itajaí (BR)
- Clinics Hospital of Ribeirão Preto (BR)
- Universidade Federal do Paraná (BR)
- Pontifícia Universidade Católica de Campinas (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Gastroenterología y Hepatología
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1016/j.gastrohep.2025.502396
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00