Centromere protein U mediates the ubiquitination and degradation of RPS3 to facilitate temozolomide resistance in glioblastoma
Our study identified CENPU as a novel key gene mediating TMZ resistance and elucidated its molecular mechanisms, providing a new target to overcome TMZ resistance in GBM.
Authors
- Lejun Zhang (ORCID: https://orcid.org/0000-0003-0874-8526)
- Jing Ren (ORCID: https://orcid.org/0000-0003-1384-7369)
- Nan Hu (ORCID: https://orcid.org/0000-0002-4046-8439)
- Wen‐Yu Zhao (ORCID: https://orcid.org/0000-0002-3422-4913)
- Yixin Xu (ORCID: https://orcid.org/0000-0003-2164-1483)
- Zhifei Wang (ORCID: https://orcid.org/0000-0002-3197-4380)
- Tao Jiang (ORCID: https://orcid.org/0000-0002-9205-8183)
- Jinmin Sun
- Haowei Cao
- Biao Xu (ORCID: https://orcid.org/0000-0003-0045-0557)
- Sicheng Wu
- Senrui Xue
- Xinmiao Li (ORCID: https://orcid.org/0000-0002-0411-0608)
- Yong Zhang (ORCID: https://orcid.org/0000-0002-7400-5803)
Institutions
- Central South University (CN)
- Xuzhou Medical College (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
- Zhujiang Hospital (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Drug Resistance Updates
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1016/j.drup.2025.101214
- Citations
- 14
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 22.76
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province