Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial
The primary analysis at week 48 showed that the antiviral efficacy of GLS4/RTV with ETV was clearly superior to that of ETV monotherapy. GLS4/RTV with ETV was well tolerated; further studies evaluating its safety and efficacy are ongoing. (clinical trial identifier: NCT04147208).
Authors
- Tao Han (ORCID: https://orcid.org/0000-0003-3814-8492)
- Yunfu Chen (ORCID: https://orcid.org/0009-0008-2305-8850)
- Jia Shang
- Junqi Niu (ORCID: https://orcid.org/0000-0001-5415-2024)
- Jinlin Hou
- Qing Xie (ORCID: https://orcid.org/0000-0003-2889-5670)
- Wenlian Xie (ORCID: https://orcid.org/0000-0001-5222-0767)
- Yulei Zhuang (ORCID: https://orcid.org/0009-0005-7322-881X)
- Jiajie Lu (ORCID: https://orcid.org/0000-0002-0865-8240)
- Robert G. Gish (ORCID: https://orcid.org/0000-0001-6306-3189)
- Jianqi Lian (ORCID: https://orcid.org/0000-0002-5549-7590)
- Peng Hu (ORCID: https://orcid.org/0000-0002-2763-4893)
- Zhiliang Gao (ORCID: https://orcid.org/0000-0002-1426-6462)
- Huiying Rao (ORCID: https://orcid.org/0000-0003-2431-3872)
- Yanhang Gao (ORCID: https://orcid.org/0000-0001-8590-6706)
- Zhenjing Jin (ORCID: https://orcid.org/0000-0002-2686-2907)
- Sujun Zheng (ORCID: https://orcid.org/0000-0002-6367-5764)
- Haibing Gao (ORCID: https://orcid.org/0000-0002-7266-1487)
- Shide Lin (ORCID: https://orcid.org/0000-0001-8803-4069)
- Yongxiang Yi (ORCID: https://orcid.org/0000-0002-9465-1212)
- Maorong Wang
- Liang Chen (ORCID: https://orcid.org/0000-0002-1437-4308)
- Mingjie Zhang (ORCID: https://orcid.org/0000-0001-9404-0190)
- Dongliang Yang (ORCID: https://orcid.org/0000-0001-5387-2660)
- Lin Luo (ORCID: https://orcid.org/0000-0002-4349-4595)
- Mingyuan Zhang (ORCID: https://orcid.org/0000-0002-4444-0097)
- Yingjun Zhang (ORCID: https://orcid.org/0000-0002-6292-8045)
- Jing Zhang (ORCID: https://orcid.org/0000-0001-8861-7336)
- Huanyu Gong (ORCID: https://orcid.org/0000-0002-5802-094X)
- Yongning Xin (ORCID: https://orcid.org/0000-0003-4679-1584)
- Chao Wu (ORCID: https://orcid.org/0009-0007-7251-8094)
- Fei Kong (ORCID: https://orcid.org/0000-0002-2029-8014)
- Youwen Tan (ORCID: https://orcid.org/0000-0002-5464-1407)
- Mao Mu (ORCID: https://orcid.org/0000-0002-1897-8221)
- Xiaorong Mao (ORCID: https://orcid.org/0000-0002-6072-679X)
- Yingren Zhao (ORCID: https://orcid.org/0000-0001-8545-4965)
Institutions
- Qingdao University (CN)
- Jiangsu University (CN)
- Fujian Medical University (CN)
- Central South University (CN)
- Guiyang Medical University (CN)
- Zunyi Medical University (CN)
- Dalian Medical University (CN)
- Jilin University (CN)
- Peking University (CN)
- Sichuan University (CN)
- Ruijin Hospital (CN)
- Tianjin Third Central Hospital (CN)
- West China Hospital of Sichuan University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- HEC Pharm (China) (CN)
- Shanghai Public Health Clinical Center (CN)
- PLA 306 Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Nanjing Drum Tower Hospital (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Qingdao Municipal Hospital (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Peking University People's Hospital (CN)
- First Hospital of Jilin University (CN)
- Wuhan Union Hospital (CN)
- The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine (CN)
- Henan Provincial People's Hospital (CN)
- Central Hospital of Putuo District (CN)
- Second Affiliated Hospital of Jilin University (CN)
- Zhenjiang City Fourth People's Hospital (CN)
- Beijing YouAn Hospital (CN)
- Beijing Ditan Hospital (CN)
- Nanjing Second Hospital (CN)
- Hepatitis B Foundation (US)
- Third Xiangya Hospital (CN)
- Huazhong University of Science and Technology Hospital (CN)
- Xijing Hospital (CN)
- Huashan Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Union Hospital (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
- Huazhong University of Science and Technology (CN)
- Tianjin Medical University (CN)
- Southern Medical University (CN)
- Lanzhou University (CN)
- Chongqing Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1016/j.jinf.2025.106446
- Citations
- 5
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.77