A375 melanoma-derived lactate controls A375 melanoma phenotypes by inducing macrophage M2 polarization <i>via</i> TCA cycle and TGF-β signaling
Our data collectively demonstrate that lactate derived from melanoma facilitates polarization of M2 macrophages, which subsequently leads to modifications in melanoma phenotypes <i>via</i> TCA cycle and TGF-β signaling.
Authors
- Zelian Qin (ORCID: https://orcid.org/0000-0003-1420-4576)
- Yurui Shi
- Hongsen Bi (ORCID: https://orcid.org/0009-0008-8119-5255)
- Zhenmin Zhao (ORCID: https://orcid.org/0000-0001-9483-6308)
- Qifei Wang (ORCID: https://orcid.org/0000-0002-0863-7730)
- Mengli Xu
- Yuhao Lu (ORCID: https://orcid.org/0009-0001-3984-2614)
- Jingyi Wang (ORCID: https://orcid.org/0000-0002-1458-4890)
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2025-02-21
- DOI
- https://doi.org/10.7717/peerj.18887
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China