To study the mutagenic potential of Artavol® using the Ame’s Test   by Microbial assay – A research article

Natural products continue to play an important role in the discovery and development of new pharmaceuticals. Several chemical compounds have been extracted and identified from its species The increasing use of herbal medicinal items calls for safety testing to protect the public from unintended hazardous effects. However, most are not tested, putting the public at risk. The modified Ames test is a useful resource for determining the mutagenic potential of medicinal products and was used this study to determine the safety of an herbal tea.In the present experiment we are discussing The Ames test has become one of the most commonly used tests to assess the mutagenic potential of medicinal plants since they have several biological activities and thus have been used in traditional medicine and in the pharmaceutical industry as a source of raw materials. Accordingly, this review aims to report previous use of the Ames test to evaluate the mutagenic potential of medicinal plants. However, the reliability of many reviewed studies regarding the botanical extracts may be questioned due to technical issues, such as testing being performed only in the presence or absence of S9, use of maximum doses below 5 mg/plate and lack of information on the cytotoxicity of tested doses. These methodological aspects additionally demonstrated that a discussion about the doses used in research on mixtures,