Sex differences in effectiveness of CGRP receptor antagonism for treatment of acute and persistent headache-like pain in a mouse model of mild traumatic brain injury
Sustained CGRP-R blockade starting soon after mTBI significantly inhibited APTH and prevented the expression of PPTH with greater analgesic effects in females compared to males. Delayed CGRP-R blockade beginning after resolution of APTH phase was minimally effective in preventing expression of PPTH in either sex. These data are consistent with previous observations that CGRP induces pain behaviors preferentially in females. Early and continuous CGRP blockade following mTBI may represent a viable treatment option for PTH treatment and the prevention of PTH persistence, especially in females.
Authors
- Kara R. Barber (ORCID: https://orcid.org/0000-0002-4042-9886)
- Todd J. Schwedt (ORCID: https://orcid.org/0000-0002-7780-7086)
- Janice Oyarzo
- Trent R. Anderson (ORCID: https://orcid.org/0000-0002-3541-7741)
- David W. Dodick (ORCID: https://orcid.org/0000-0002-9486-6790)
- Edita Navratilova (ORCID: https://orcid.org/0000-0002-1497-125X)
- Frank Porreca (ORCID: https://orcid.org/0000-0002-2267-0617)
- Caroline Machado Kopruszinski (ORCID: https://orcid.org/0000-0002-5392-5117)
Institutions
- University of Arizona (US)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Cephalalgia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1177/03331024251321087
- Citations
- 6
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- U.S. Department of Defense