A newly designed flexible hydrated-hardening bone graft (FHBG) promotes bone regeneration and in vivo calvarial repair
FHBG significantly promotes bone regeneration both in vitro and in vivo. Additionally, FHBG has been demonstrated to be safe, with fewer residuals remaining in the body compared to currently in-use clinical bone grafts. This study validates the ability of the newly designed FHBG to facilitate osteogenesis in vitro and demonstrates its efficacy and safety in new bone formation in vivo. The lower residual material further suggests a reduced long-term impact and associated risk with the graft.
Authors
- Rong‐Fu Chen (ORCID: https://orcid.org/0000-0001-7529-5390)
- Kuan-Yu Chiu
- Y. Austin Chang
- Yi‐Chia Wu (ORCID: https://orcid.org/0000-0002-1204-5973)
- Huan-Chieh Cho
- Li-Wen Weng
- Su‐Shin Lee (ORCID: https://orcid.org/0000-0001-8675-0870)
- Chun‐Chieh Tseng (ORCID: https://orcid.org/0000-0002-2036-7243)
- Wei‐Ting Wang (ORCID: https://orcid.org/0000-0001-9479-5518)
Institutions
- Kaohsiung Medical University (TW)
- National Taiwan University of Science and Technology (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Metal Industries Research & Development Centre (TW)
Publication Details
- Journal
- Biomedical Journal
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1016/j.bj.2025.100836
- Citations
- 1
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.67
Funders
- Kaohsiung Medical University
- Kaohsiung Medical University Chung-Ho Memorial Hospital