Age- and sex-dependency of thrombin generation parameters in the general Italian population: the Moli-sani study
The TG profile becomes more "procoagulant" at older age, especially in women. The sensitivity of the APC pathway to TM is reduced with increasing age in men and women. Therefore, age and sex appropriate reference values for TG parameters would be of interest for the ongoing clinical implementation of the TG assay.
Authors
- Marisa Ninivaggi (ORCID: https://orcid.org/0000-0002-3133-1596)
- Simona Costanzo (ORCID: https://orcid.org/0000-0003-4569-1186)
- Lisa N. van der Vorm (ORCID: https://orcid.org/0000-0003-0698-5878)
- Augusto Filippo Di Castelnuovo (ORCID: https://orcid.org/0000-0001-9767-7998)
- Chiara Cerletti (ORCID: https://orcid.org/0000-0002-4759-3179)
- Licia Iacoviello (ORCID: https://orcid.org/0000-0003-0514-5885)
- Maria Benedetta Donati (ORCID: https://orcid.org/0000-0003-1747-5443)
- Bas de Laat (ORCID: https://orcid.org/0000-0001-9596-1944)
- Amalia De Curtis (ORCID: https://orcid.org/0000-0001-5104-0318)
- Romy de Laat‐Kremers
Institutions
- Libera Università Maria SS. Assunta (IT)
- Istituto Neurologico Mediterraneo (IT)
- Synapse (Netherlands) (NL)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.3389/fcvm.2025.1528871
- Citations
- 1
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.77