Daily fluid intake and brain amyloid deposition: A cohort study
BackgroundLittle information is yet available for the association between daily water intake, a modifiable lifestyle factor, and Alzheimer's disease (AD) pathology and cerebrovascular injury in the living human brain.ObjectiveOur aim was to explore the correlation between daily fluid intake and in vivo AD pathologies (i.e., amyloid-β (Aβ) and tau) and cerebrovascular injury.Methods287 cognitively normal (CN) older adults completed extensive clinical assessments, daily fluid intake evaluations, and multimodal brain imaging at both the initial baseline and the subsequent 2-year follow-up.ResultsLow daily fluid intake was significantly associated with a higher level or a more rapid increase of Aβ deposition, especially in apolipoprotein E4 negative individuals. Meanwhile, low daily fluid intake was cross-sectionally related with cerebrovascular injury.ConclusionsOur findings suggest that high daily fluid intake is associated with decreased brain amyloid deposition, indicating that sufficient daily fluid intake may be helpful for prevention of AD.
Authors
- Yoon Young Chang (ORCID: https://orcid.org/0009-0006-0279-1880)
- Yu Kyeong Kim (ORCID: https://orcid.org/0000-0002-3282-822X)
- Gijung Jung (ORCID: https://orcid.org/0000-0001-5952-3373)
- Nayeong Kong (ORCID: https://orcid.org/0000-0002-9095-1701)
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Joon Hyung Jung (ORCID: https://orcid.org/0000-0003-1669-6113)
- Yunsang Lee
- Koung Mi Kang (ORCID: https://orcid.org/0000-0001-9643-2008)
- Hyejin Ahn (ORCID: https://orcid.org/0000-0002-6613-4680)
- Jee Wook Kim (ORCID: https://orcid.org/0000-0002-9570-4216)
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Chul‐Ho Sohn (ORCID: https://orcid.org/0000-0003-0039-5746)
- Jun‐Young Lee (ORCID: https://orcid.org/0000-0002-5893-3124)
- Dong Young Lee (ORCID: https://orcid.org/0000-0001-8976-8320)
Institutions
- Seoul National University (KR)
- Hallym University (KR)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Inje University Sanggye Paik Hospital (KR)
- Hallym University Dongtan Sacred Heart Hospital (KR)
- Chungbuk National University Hospital (KR)
- Keimyung University (KR)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1177/13872877251314176
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Korea Health Industry Development Institute
- Ministry of Science and ICT, South Korea
- National Institute on Aging