Histopathologic Concerns and Diagnostic Challenges in Hirschsprung’s Disease: An Eastern European Single-Center Observational Study
Coupled calretinin-CD56 immunohistochemistry is useful in diagnosing ganglion cell paucity biopsies or specimens with incomplete submucosa. In cases where there are no ganglion cells but there are calretinin-positive nerve fibrils in the lamina propria without nerve trunk (NT) hypertrophy, re-biopsy is the best solution. The significant differences in NT size between biopsies and surgical specimens highlight the importance of assessing NT diameter in all tissue samples examined.
Authors
- Zoltán Derzsi (ORCID: https://orcid.org/0000-0001-6591-520X)
- Zsolt Bara (ORCID: https://orcid.org/0009-0009-1526-6972)
- Horea Gozar (ORCID: https://orcid.org/0009-0003-6749-4711)
- Emőke Horváth (ORCID: https://orcid.org/0000-0001-6235-6959)
- Evelyn Kovács (ORCID: https://orcid.org/0009-0009-9413-1637)
- G. Molnár
- Eliza Löckli
Institutions
- Clinical Emergency Hospital Bucharest (RO)
- Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș (RO)
Publication Details
- Journal
- Life
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3390/life15030329
- Primary Topic
- Congenital gastrointestinal and neural anomalies
- Type
- article
- Field-Weighted Citation Impact
- 0.00