Acceptability of an annual tenofovir alafenamide implant for HIV prevention in South African women: findings from the CAPRISA 018 Phase I clinical trial
While implant attributes, physical experiences and insertion/removal procedures were largely acceptable, local ISRs significantly reduced tolerability and acceptability, resulting in higher-than-expected early removals. The potential benefits of an annual TAF implant may be undermined unless tolerability is improved.
Authors
- John A. Moss (ORCID: https://orcid.org/0000-0001-8091-3245)
- Lara Lewis (ORCID: https://orcid.org/0000-0001-5373-2086)
- Bruno Pozzetto (ORCID: https://orcid.org/0000-0002-2603-8467)
- Catherine Hankins (ORCID: https://orcid.org/0000-0002-1642-8592)
- Ishana Harkoo
- James F. Rooney (ORCID: https://orcid.org/0000-0003-3261-0711)
- Craig J. Heck (ORCID: https://orcid.org/0000-0002-8138-6640)
- Quarraisha Abdool Karim (ORCID: https://orcid.org/0000-0002-0985-477X)
- Leila E. Mansoor (ORCID: https://orcid.org/0000-0002-7607-348X)
- Salim S. Abdool Karim (ORCID: https://orcid.org/0000-0002-4986-2133)
- Marc M. Baum (ORCID: https://orcid.org/0000-0003-1558-5649)
- Tanuja N. Gengiah (ORCID: https://orcid.org/0000-0002-3405-5128)
- Nqobile Myeni
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Columbia University Irving Medical Center (US)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Oak Crest Institute of Science (US)
- Amsterdam Institute for Global Health and Development (NL)
- Gilead Sciences (United States) (US)
- Centre International de Recherche en Infectiologie (FR)
- Columbia University (US)
- Université Jean Monnet (FR)
Publication Details
- Journal
- Journal of the International AIDS Society
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jia2.26426
- Citations
- 2
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 2.79