Vitamin D impedes eosinophil chemotaxis via inhibiting glycolysis-induced CCL26 expression in eosinophilic chronic rhinosinusitis with nasal polyps
VD impedes eosinophil chemotaxis by inhibiting glycolysis - induced CCL26 expression via attenuating the activation of the ERK pathway and reducing lactate production. VD supplementation may be a novel strategy to treat ECRSwNP.
Authors
- Xifu Wu (ORCID: https://orcid.org/0000-0001-7181-304X)
- Gehua Zhang (ORCID: https://orcid.org/0000-0002-1917-0283)
- Yanjie Jiang (ORCID: https://orcid.org/0000-0001-6404-9143)
- Yana Zhang (ORCID: https://orcid.org/0000-0003-0405-2943)
- Yue Li (ORCID: https://orcid.org/0000-0002-2353-4078)
- Jun Ma (ORCID: https://orcid.org/0000-0002-7566-4317)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-2139-3697)
- Xia Li (ORCID: https://orcid.org/0000-0001-5429-1657)
- Haotian Wu
- Donglin Li (ORCID: https://orcid.org/0000-0002-8825-6806)
- Weiqiang Huang (ORCID: https://orcid.org/0000-0003-3854-847X)
- Xiaoping Lai (ORCID: https://orcid.org/0000-0002-9063-3498)
- Zizhen Huang (ORCID: https://orcid.org/0000-0001-6390-8508)
- Lihong Chang (ORCID: https://orcid.org/0000-0001-8668-1916)
- Jianqi Wang
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s12964-025-02078-2
- Citations
- 9
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 16.63
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province