A short-term, high-caloric diet has prolonged effects on brain insulin action in men
Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.
Authors
- Norbert Stefan (ORCID: https://orcid.org/0000-0002-2186-9595)
- Robert Hauffe (ORCID: https://orcid.org/0000-0003-3403-6573)
- Martin Heni (ORCID: https://orcid.org/0000-0002-8462-3832)
- Andreas L. Birkenfeld (ORCID: https://orcid.org/0000-0003-1407-9023)
- Stephanie Kullmann (ORCID: https://orcid.org/0000-0001-9951-923X)
- Jürgen Machann (ORCID: https://orcid.org/0000-0002-4458-5886)
- Lore Wagner (ORCID: https://orcid.org/0000-0002-8868-9281)
- Corinna Dannecker
- Leontine Sandforth
- André Kleinridders (ORCID: https://orcid.org/0000-0002-4248-6366)
- Ralf Veit (ORCID: https://orcid.org/0000-0001-9860-642X)
- Andreas Fritsche (ORCID: https://orcid.org/0000-0002-4987-1961)
- Hubert Preißl (ORCID: https://orcid.org/0000-0002-8859-4661)
- Nils B. Kroemer (ORCID: https://orcid.org/0000-0002-9552-3781)
- Anne Kühnel (ORCID: https://orcid.org/0000-0003-3066-3801)
Institutions
- University of Bonn (DE)
- University of Potsdam (DE)
- Universität Ulm (DE)
- University Children's Hospital Tübingen (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- German Institute of Human Nutrition (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Nature Metabolism
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1038/s42255-025-01226-9
- Citations
- 17
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 15.55
Funders
- Bundesministerium für Bildung und Forschung
- Helmholtz Zentrum München