Fast Esterification Method Mediated by Coupling Reagent NDTP
Herein, we report a rapid and mild esterification method using 5-nitro-4,6-dithiocyanatopyrimidine (NDTP) as a coupling reagent, which is effective in alcoholic and nonalcoholic solvents. The esterification process mediated by NDTP allows for the good yield synthesis of esters within just 1 min. A wide range of alcohols and carboxylic acids were effectively esterified under these optimized conditions. The method's rapid execution, high efficiency, and adaptability across diverse substrates make it advantageous for ester synthesis.
Authors
- Haoyu Kuang
- Yiping Li (ORCID: https://orcid.org/0009-0009-9665-858X)
- Guangjun Bao
- Wangsheng Sun (ORCID: https://orcid.org/0000-0001-5277-3329)
- Zhouming Shen
Institutions
- Academy of Medical Sciences (GB)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1021/acsomega.4c09365
- Citations
- 5
- Primary Topic
- Innovative Microfluidic and Catalytic Techniques Innovation
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Fundamental Research Funds for the Central Universities