Genetic evidence identifies a causal relationship between EBV infection and multiple myeloma risk
The findings of this study suggest that EBNA-1 antibodies may increase the risk of MM by downregulating HLA-DR⁺ mDC. This indicates that chronic EBV infection may contribute to an elevated risk of MM. We hope these results provide new insights for future research on the prevention and treatment of MM.
Authors
- Jie Tian (ORCID: https://orcid.org/0000-0003-4182-3495)
- Rong Tan (ORCID: https://orcid.org/0000-0003-0747-5554)
- Bing Yang (ORCID: https://orcid.org/0000-0001-6183-8163)
- Jian Li (ORCID: https://orcid.org/0000-0002-5807-2360)
- Dongxin Tang (ORCID: https://orcid.org/0000-0003-0400-5549)
- Yang Zhu (ORCID: https://orcid.org/0000-0002-7384-607X)
- Changpu Du
Institutions
- Guiyang College of Traditional Chinese Medicine (CN)
- Guizhou University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1038/s41598-025-90479-1
- Citations
- 4
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China