Senescent alveolar type II epithelial cells-secreted GDF15 promotes silicosis progression via interfering intercellular communication
Our results elucidate that senescence ATII cell-secreted GDF15 plays a vital role in promoting silicosis by influencing surrounding cells, and provides scientific clues for the selection of potential therapeutic drugs for silicosis.
Authors
- Zhenhua Jia (ORCID: https://orcid.org/0000-0001-5132-1099)
- Xinying Jia
- Chunhui Ni (ORCID: https://orcid.org/0000-0002-6539-2434)
- Demin Cheng
- Wenqing Sun (ORCID: https://orcid.org/0000-0001-6234-5301)
- Yi Liu (ORCID: https://orcid.org/0000-0002-3744-0590)
- Ting Wang (ORCID: https://orcid.org/0000-0002-6569-4395)
- Wenxiu Lian
Institutions
- Nantong University (CN)
- Hebei Yiling Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Ministry of Education (KR)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.117917
- Citations
- 6
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 10.01
Funders
- National Natural Science Foundation of China