Evaluation of the Efficacy of Colchicine, Pirfenidone and Prednisolone in Preventing Stricture Due to Inflammation as a Result of Urethral Mucosal Damage in Rats

What's known on the subject? and What does the study add?Urethral stricture is a disease characterized by fibrotic scar formation causing narrowing of the urethra, decreased urethral volume, and failure of normal voiding function, and can frequently recur despite endoscopic or open surgical treatment.We administered pirfenidone, colchicine, and corticosteroids orally to prevent proliferation, excessive fibrosis, and scarring during the healing process of urethral stricture.This is the only study in the literature comparing three oral pharmacological agents with known anti-inflammatory and antifibrotic properties to prevent recurrence of urethral stricture.As a result of clinical studies, we believe that the use of these agents before and after all interventions for urethral stricture should be included in clinical practice.