NHC‐Organocatalyzed Multicomponent Fluorination and Fluoroalkylation for Access to Fluorine‐Containing Compounds

Abstract Fluorine‐containing compounds have garnered significant attention in organic synthesis, pharmaceuticals, and agrochemicals. The development of efficient methods for constructing fluorinated structures has become a critical topic in organic synthesis. Additionally, N ‐heterocyclic carbene (NHC)‐organocatalyzed multicomponent fluorination and fluoroalkylation have emerged as a powerful strategy for accessing diverse fluorinated compounds. The minireview summarizes the construction of fluorine‐containing compounds via NHC‐organocatalyzed multicomponent reactions over the past 15 years. Key reaction types include: i) NHC‐catalyzed electrophilic fluorination and trifluoromethylation; and ii) NHC‐catalyzed radical fluoroalkylation and cooperative NHC / transition metal catalyzed radical fluoroalkylation. Perspectives and insights into recent advancements in the research field are also provided at the end of the review.