Inhibition of renin-angiotensin system attenuates type I alveolar epithelial cell necroptosis in rats after hyperbaric hyperoxic exposure
Our study indicates inhibition of RAS can suppress the hyperbaric HLI, which may be, at least partially, related to the inhibition of type I AECs necroptosis. Our findings provide new mechanism for the protective effects of RAS inhibition on hyperbaric HLI.
Authors
- P.X. Zhang
- Shifeng Wang (ORCID: https://orcid.org/0000-0001-6169-2598)
- Wenwu Liu (ORCID: https://orcid.org/0000-0003-1530-8860)
- Cuihong Han
- Jiajun Xu (ORCID: https://orcid.org/0000-0001-5010-2986)
- Ying Liu (ORCID: https://orcid.org/0000-0002-7432-2219)
- Xueying Yu (ORCID: https://orcid.org/0000-0002-2109-3301)
- Yumei Wen
Institutions
- Jining First People's Hospital (CN)
- Yantaishan Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.3389/fmed.2025.1521729
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00