Ir-Catalyzed, Nitrogen-Directed C(sp<sup>3</sup>)–H and C(sp<sup>2</sup>)–H Borylation with a Spiro-Fluorene-Indenoindenyl Ligand
We have developed a strategy to facilitate the nitrogen-directed C–H borylation using an Ir(cod) catalyst with a spiro-fluorene-indenoindenyl (SFI) ligand through CH (ligand)−π (substrate) interactions and the selective formation of an electron-rich and less bulky IrH(Bpin) intermediate rather than Ir(Bpin)2. This Ir catalyst allows the nitrogen-directed regioselective C(sp3)–H and C(sp2)–H borylation with HBpin at near room temperature without photoirradiation with a broad substrate scope.
Authors
- Yu Sato (ORCID: https://orcid.org/0000-0003-1084-6475)
- Ken Tanaka (ORCID: https://orcid.org/0000-0003-0534-7559)
- Yuki Nagashima (ORCID: https://orcid.org/0000-0001-8470-5638)
- Tomonori Inoue
Institutions
- Shanghai Institute for Science of Science (CN)
- Institute of Science Tokyo (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1021/acscatal.4c07249
- Citations
- 4
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- Japan Society for the Promotion of Science