The Facile Synthesis of Exogenous Lewis-Base-Free Amidoalanes: A Structural Comparison
A simple one-pot reaction of LiAlH<sub>4</sub>, AlCl<sub>3</sub>, and a secondary amine HNR<sub>2</sub> [R = Et, <i><sup>i</sup></i>Pr, <i><sup>i</sup></i>Bu, cyclo-C<sub>6</sub>H<sub>11</sub>, (CH<sub>2</sub>)<sub>4</sub>, and (CH<sub>2</sub>)<sub>5</sub>] in hydrocarbon solvents results in the formation of exogenous Lewis-base-free amidoalanes [H<sub>2</sub>Al(NR<sub>2</sub>)]<sub>n</sub> (n = 2 or 3) as crystalline solids (35-85% yield). In the solid state (seven X-ray structures), all the amidoalanes exist as dimers, with the exception of the pyrrolidine-derived alane which exists as a trimer. As solids, these amidoalanes exhibit significant kinetic stability towards oxygen/moisture allowing the brief (ca. 5 min.) handling of [H<sub>2</sub>Al(N<i><sup>i</sup></i>Pr<sub>2</sub>)]<sub>2</sub> in air.
Authors
- William Lewis (ORCID: https://orcid.org/0000-0001-7103-6981)
- Simon Woodward (ORCID: https://orcid.org/0000-0001-8539-6232)
- Darren Willcox (ORCID: https://orcid.org/0000-0002-1396-7734)
- Andrej Vinogradov
- Jake Hemsworth
Institutions
- University of Nottingham (GB)
- University of Manchester (GB)
Publication Details
- Journal
- Molecules
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3390/molecules30050986
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Engineering and Physical Sciences Research Council