miRNA-503 inhibition exerts anticancer effects and reduces tumor growth in mesothelioma
Our study is the first reporting an oncomiR role for miR-503 in MM and suggests that its inactivation could have a clinical value in MM patients. This study reveals that miRNA-503 acts as an oncomiR in MM suggesting that its inhibition, through LNP delivery, has the potential to be considered as a novel therapeutic strategy in MM.
Authors
- Federica Monaco (ORCID: https://orcid.org/0000-0002-9798-3589)
- Alfonso Baldi (ORCID: https://orcid.org/0000-0002-8693-3842)
- Raffaele Calogero (ORCID: https://orcid.org/0000-0002-2848-628X)
- Mariateresa Mancuso (ORCID: https://orcid.org/0000-0002-0912-9287)
- Giuseppe De Rosa (ORCID: https://orcid.org/0000-0002-1210-1269)
- Rossana Cuciniello (ORCID: https://orcid.org/0000-0001-5768-4528)
- Gaia Goteri (ORCID: https://orcid.org/0000-0001-5198-8387)
- Gianfranco Peluso (ORCID: https://orcid.org/0000-0003-4352-9484)
- Mirella Tanori (ORCID: https://orcid.org/0000-0001-8020-2224)
- Stefania Crispi (ORCID: https://orcid.org/0000-0002-7566-1554)
- Francesco Di Meo (ORCID: https://orcid.org/0000-0003-4833-8951)
- Maddalena Arigoni (ORCID: https://orcid.org/0000-0003-4629-3841)
- Anna Valentino (ORCID: https://orcid.org/0000-0001-8041-2221)
- Marco Tomasetti (ORCID: https://orcid.org/0000-0001-5036-7052)
- Enrico P. Spugnini (ORCID: https://orcid.org/0000-0003-3487-485X)
- Virginia Campani
- M. Piccioni (ORCID: https://orcid.org/0009-0002-7022-7705)
Institutions
- National Agency for New Technologies, Energy and Sustainable Economic Development (IT)
- Marche Polytechnic University (IT)
- Centre National de la Recherche Scientifique (FR)
- Aix-Marseille Université (FR)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Institute of Biosciences and Bioresources (IT)
- Institute of Ecosystem Study (IT)
- Link Campus University (IT)
- University of Turin (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1186/s13046-025-03283-0
- Citations
- 5
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Consiglio Nazionale delle Ricerche
- Ministero dello Sviluppo Economico
- Regione Basilicata
- Ministero dell'Università e della Ricerca