Synthesis of Benzo[c]isothiazole 2-Oxides via Copper-Catalyzed Cycloamidation Reaction
Abstract Herein, a modular and efficient approach towards benzo[c]isothiazole 2-oxides via a copper-catalyzed intramolecular C–N cross-coupling reaction was disclosed. Readily available starting materials, broad substrate scope, outstanding yields (up to 95%), and scalability were observed, highlighting its potential in the pharmaceutical and chemical industries.
Authors
- Limin Yu (ORCID: https://orcid.org/0009-0000-1265-0244)
- Yimiao He (ORCID: https://orcid.org/0009-0003-7416-4446)
- Jie Weng (ORCID: https://orcid.org/0000-0002-7034-3215)
- Yuan He (ORCID: https://orcid.org/0000-0002-1712-0776)
- Jin Meng (ORCID: https://orcid.org/0000-0003-2611-5407)
Institutions
- Hengyang Academy of Agricultural Sciences (CN)
- Nanning Normal University (CN)
Publication Details
- Journal
- Synlett
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1055/a-2544-3496
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- National Natural Science Foundation of China