Isolated Atrial Amyloidosis in a Patient with Aortic Regurgitation and Paroxysmal Atrial Fibrillation

A 65-year-old woman was admitted to our hospital with heart failure secondary to aortic regurgitation and paroxysmal atrial fibrillation (AF). During surgery for valve-sparing aortic root replacement, a biopsy was obtained from the right atrium because of paroxysmal AF and mild left ventricular hypokinesis. A histopathological examination revealed atrial natriuretic peptide amyloidosis, and the patient was clinically diagnosed with isolated atrial amyloidosis (IAA). Although IAA is rarely diagnosed clinically, it should be considered in patients with AF and heart failure.

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Publication Details

Journal
Internal Medicine
Published
2025-02-21
DOI
https://doi.org/10.2169/internalmedicine.5049-24
Primary Topic
Amyloidosis: Diagnosis, Treatment, Outcomes
Type
article
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article

Isolated Atrial Amyloidosis in a Patient with Aortic Regurgitation and Paroxysmal Atrial Fibrillation

Ichiro Matsumaru, Chikara Ohno, Tsuyoshi Yoshimuta, Takashi Miura et al.
Internal Medicine
Amyloidosis: Diagnosis, Treatment, Outcomes
article

Isolated Atrial Amyloidosis in a Patient with Aortic Regurgitation and Paroxysmal Atrial Fibrillation

Ichiro Matsumaru, Chikara Ohno, Tsuyoshi Yoshimuta, Takashi Miura, Akira Senoo, Takashi Kudo, Mitsuharu Ueda, Koji Maemura, Hiroaki Kawano, Masahiro Nakashima, Nozomi Ueki
article en

Abstract

A 65-year-old woman was admitted to our hospital with heart failure secondary to aortic regurgitation and paroxysmal atrial fibrillation (AF). During surgery for valve-sparing aortic root replacement, a biopsy was obtained from the right atrium because of paroxysmal AF and mild left ventricular hypokinesis. A histopathological examination revealed atrial natriuretic peptide amyloidosis, and the patient was clinically diagnosed with isolated atrial amyloidosis (IAA). Although IAA is rarely diagnosed clinically, it should be considered in patients with AF and heart failure.

Internal MedicineVol. 64(17)
Nagasaki University Hospital (JP), Nagasaki University (JP), Kumamoto University (JP)
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Openalex Percentile: Top 97%
Amyloidosis: Diagnosis, Treatment, Outcomes
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Isolated Atrial Amyloidosis in a Patient with Aortic Regurgitation and Paroxysmal Atrial Fibrillation — Ichiro Matsumaru, Chikara Ohno, et al. · Internal Medicine (2025) | TGRS Research Map | TGRS