Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways
These findings underscore the fundamental role of c-REL in endothelial responses to disturbed flow and highlight therapeutic targeting of endothelial c-REL as a potential strategy for atherosclerosis treatment.
Authors
- Blanca Tardajos Ayllón (ORCID: https://orcid.org/0000-0001-6466-8366)
- Fiona Oakley (ORCID: https://orcid.org/0000-0001-8692-1836)
- Suowen Xu (ORCID: https://orcid.org/0000-0002-5488-5217)
- D. Mark Pritchard (ORCID: https://orcid.org/0000-0001-7971-3561)
- Carrie A. Duckworth (ORCID: https://orcid.org/0000-0001-9992-7540)
- Jovana Serbanovic‐Canic (ORCID: https://orcid.org/0000-0002-8835-1491)
- Céline Souilhol
- Hisham M. Darwish
- Jon R. Sayers (ORCID: https://orcid.org/0000-0002-5082-1443)
- Neil Bowden (ORCID: https://orcid.org/0000-0001-6825-7759)
- Sheila Francis (ORCID: https://orcid.org/0000-0001-6552-0339)
- Paul C. Evans (ORCID: https://orcid.org/0000-0001-7975-681X)
- Siyu Tian (ORCID: https://orcid.org/0000-0002-5854-1243)
Institutions
- University of Science and Technology of China (CN)
- University of Liverpool (GB)
- Queen Mary University of London (GB)
- Chinese Academy of Sciences (CN)
- Hefei Institutes of Physical Science (CN)
- Insigneo (GB)
- William Harvey Research Institute (GB)
- Newcastle University (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1093/cvr/cvaf024
- Citations
- 6
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- British Heart Foundation
- Medical Research Council