One-Pot NIS-Promoted Cyclization/Palladium-Catalyzed Carbonylation for the Selective Synthesis of HFIP Ester-Containing Indenes and Thiochromenes

Practical and atom-economic procedures for the selective synthesis of HFIP ester-containing indenes/thiochromenes from the same propargylic thioethers and HFIP have been developed via one-pot NIS-promoted cyclization/palladium-catalyzed carbonylation. Solvent plays an important role in this transformation, and the reactions proceed selectively and efficiently to afford a variety of HFIP ester-containing indenes and thiochromenes in moderate to excellent yields. In addition, the use of formic acid as the CO source could avoid manipulation of toxic CO gas.