Mitochondrial metabolism-related features guiding precision subtyping and prognosis in breast cancer, revealing FADS2 as a novel therapeutic target
This study reveals that mitochondrial metabolism-related genes are closely associated with breast cancer progression, clinical outcomes, and genetic alterations. The findings may offer new avenues for treatment strategies, early intervention, and prognosis prediction in breast cancer.
Authors
- Yakun Kang
- Nuo Chen (ORCID: https://orcid.org/0000-0002-1338-1880)
- Yuhan Dai
- Meng You (ORCID: https://orcid.org/0000-0001-6189-1845)
- Fei Li
- Yangyang Cui (ORCID: https://orcid.org/0009-0009-1107-9301)
- Hui Xie (ORCID: https://orcid.org/0000-0002-7783-413X)
- J. Jin
Institutions
- Zhongda Hospital Southeast University (CN)
- Suzhou Municipal Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1016/j.tranon.2025.102330
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Xisike Clinical Oncology Research Foundation
- National Natural Science Foundation of China
- Suzhou Municipal Science and Technology Bureau