Modular dynamics paradigm in biosystems multilevel modeling: Software design and PBPK/PD validation

The study confirms that the modular dynamics paradigm can be implemented under modern acausal OOML M&S tools to facilitate the discovery and addition of new mechanistic knowledge in biosystems models. CybSim is a novel graphical modular modeling tool for biosystems that incorporates this paradigm and has been validated under several scenarios for the PBPK modeling approach.

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Publication Details

Journal
Computers in Biology and Medicine
Published
2025-02-21
DOI
https://doi.org/10.1016/j.compbiomed.2025.109856
Citations
1
Primary Topic
Gene Regulatory Network Analysis
Type
article
Field-Weighted Citation Impact
0.81

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article

Modular dynamics paradigm in biosystems multilevel modeling: Software design and PBPK/PD validation

Manuel Prado-Velasco
1 citations
Computers in Biology and Medicine
Gene Regulatory Network Analysis
0.81
article

Modular dynamics paradigm in biosystems multilevel modeling: Software design and PBPK/PD validation

Manuel Prado-Velasco
article en
1 citations

Abstract

The study confirms that the modular dynamics paradigm can be implemented under modern acausal OOML M&S tools to facilitate the discovery and addition of new mechanistic knowledge in biosystems models. CybSim is a novel graphical modular modeling tool for biosystems that incorporates this paradigm and has been validated under several scenarios for the PBPK modeling approach.

Computers in Biology and MedicineVol. 188
Universidad de Sevilla (ES)
Universidad de Sevilla
Industry, innovation and infrastructure
Openalex Percentile: Top 31%
Gene Regulatory Network Analysis
0.81
DOIOpen Access PDFOpenAlex
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Modular dynamics paradigm in biosystems multilevel modeling: Software design and PBPK/PD validation — Manuel Prado-Velasco · Computers in Biology and Medicine (2025) | TGRS Research Map | TGRS