Erythrocyte Methotrexate–Polyglutamate Concentrations in Pediatric Inflammatory Bowel Disease
We observed high interindividual variability in the reached erythrocyte MTX-PG concentrations. Body surface adjusted or unadjusted MTX dosage showed a positive linear correlation with erythrocyte MTX-PG concentrations in children with IBD. This is a prerequisite for TDM and provides a strong basis for further research into the relation between TDM of MTX, efficacy, and toxicity.
Authors
- Nanne K.H. de Boer (ORCID: https://orcid.org/0000-0001-8357-9887)
- Maja Bulatović (ORCID: https://orcid.org/0000-0002-1053-7739)
- Johan Van Limbergen (ORCID: https://orcid.org/0000-0001-5822-4371)
- Tim G. J. de Meij (ORCID: https://orcid.org/0000-0002-7556-5896)
- Róbert de Jonge (ORCID: https://orcid.org/0000-0002-3454-0094)
- Marry Lin (ORCID: https://orcid.org/0009-0003-0474-5843)
- Eduard A. Struys (ORCID: https://orcid.org/0009-0002-8437-4108)
- Eva Vermeer (ORCID: https://orcid.org/0009-0009-4335-0100)
Institutions
- University Medical Center Utrecht (NL)
- Emma Kinderziekenhuis (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1093/ibd/izaf035
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82