Body composition and checkpoint inhibitor treatment outcomes in advanced melanoma: a multicenter cohort study
Our findings suggest that underweight BMI is associated with worse PFS, whereas higher skeletal muscle density and lower visceral adipose tissue index were associated with improved OS. These associations were independent of known prognostic factors, including sex, age, performance status, and extent of disease. No significant association between higher BMI and survival outcomes was observed.
Authors
- Pim A. de Jong (ORCID: https://orcid.org/0000-0003-4840-6854)
- Martijn F. Boomsma (ORCID: https://orcid.org/0000-0002-7878-0970)
- Mark Schuiveling (ORCID: https://orcid.org/0000-0002-2631-7271)
- Isabella A.J. van Duin (ORCID: https://orcid.org/0000-0002-9583-7115)
- Mitko Veta (ORCID: https://orcid.org/0000-0003-1711-3098)
- Geke A.P. Hospers (ORCID: https://orcid.org/0000-0002-3047-7892)
- John B.A.G. Haanen (ORCID: https://orcid.org/0000-0001-5884-7704)
- Mariëtte Labots (ORCID: https://orcid.org/0000-0002-7095-1771)
- Wouter A. C. van Amsterdam (ORCID: https://orcid.org/0000-0002-3181-0810)
- Djura Piersma (ORCID: https://orcid.org/0000-0001-5233-0296)
- Ellen Kapiteijn (ORCID: https://orcid.org/0000-0002-4814-6426)
- Gerard Vreugdenhil (ORCID: https://orcid.org/0000-0002-8816-1540)
- P. J. van Diest (ORCID: https://orcid.org/0000-0003-0658-2745)
- Femke Burgers (ORCID: https://orcid.org/0000-0002-7279-9216)
- Tim Leiner (ORCID: https://orcid.org/0000-0003-1885-5499)
- Wouter B. Veldhuis (ORCID: https://orcid.org/0000-0002-9798-6843)
- Laurens S. ter Maat
- Josien P. W. Pluim (ORCID: https://orcid.org/0000-0001-7327-9178)
- Rik J. Verheijden (ORCID: https://orcid.org/0000-0003-1966-1063)
- Jan Willem de Groot
- Pim Moeskops (ORCID: https://orcid.org/0000-0002-8733-6716)
- Hans M. Westgeest (ORCID: https://orcid.org/0000-0002-5735-3638)
- Sjoerd G. Elias (ORCID: https://orcid.org/0000-0003-3903-4024)
- Karijn P.M. Suijkerbuijk (ORCID: https://orcid.org/0000-0003-3604-5430)
- Joost J.C. Verhoeff (ORCID: https://orcid.org/0000-0001-9673-0793)
- Max F. Troenokarso
- Franchette W.P.J. van den Berkmortel
- Marye J. Boers‐Sonderen (ORCID: https://orcid.org/0009-0005-9624-9189)
Institutions
- Quanta Technology (United States) (US)
- Mayo Clinic (US)
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- University of Groningen (NL)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- Medisch Spectrum Twente (NL)
- Centre Hospitalier Universitaire Vaudois (CH)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- University Medical Center Utrecht (NL)
- Amphia Ziekenhuis (NL)
- Amsterdam Neuroscience (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Oncode Institute (NL)
- Mayo Clinic in Arizona (US)
- Máxima Medisch Centrum (NL)
- Zuyderland Medisch Centrum (NL)
- Isala (NL)
- Mayo Clinic in Florida (US)
- Eindhoven University of Technology (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1093/jnci/djaf039
- Citations
- 6
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- ZonMw