Synthesis and crystal structure of a nickel(II) 2′-deoxy-6-thioguanosine nitrate complex

The reaction of Ni(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O with the thio-modified nucleoside 2'-deoxy-6-thioguanosine (d-tG, C<sub>10</sub>H<sub>13</sub>N<sub>5</sub>O<sub>3</sub>S) in methanol in a 1:1.3 stoichiometric ratio deposited the title compound, [Ni(d-tG)<sub>3</sub>](NO<sub>3</sub>)<sub>2</sub>·2H<sub>2</sub>O, as green crystals. Despite the <1:3 Ni-ligand ratio used in the synthesis, the deoxy-thioguanosine binds to form three N<sup>7</sup>,S<sup>6</sup>-coordinated five-membered chelate rings with individual Ni<sup>II</sup> ions in mononuclear complexes rather than bridge metal centres into more extended oligomeric or polymeric structures.

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Journal
Acta Crystallographica Section C Structural Chemistry
Published
2025-02-21
DOI
https://doi.org/10.1107/s2053229625001500
Primary Topic
Synthesis and Characterization of Heterocyclic Compounds
Type
article
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0.00

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article

Synthesis and crystal structure of a nickel(II) 2′-deoxy-6-thioguanosine nitrate complex

Andrew Houlton, Andrew R. Pike, W. Clegg, Samira Hribesh et al.
Acta Crystallographica Section C Structural Chemistry
Synthesis and Characterization of Heterocyclic Compounds
article

Synthesis and crystal structure of a nickel(II) 2′-deoxy-6-thioguanosine nitrate complex

Andrew Houlton, Andrew R. Pike, W. Clegg, Samira Hribesh, Ross W. Harrington
article en

Abstract

The reaction of Ni(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O with the thio-modified nucleoside 2'-deoxy-6-thioguanosine (d-tG, C<sub>10</sub>H<sub>13</sub>N<sub>5</sub>O<sub>3</sub>S) in methanol in a 1:1.3 stoichiometric ratio deposited the title compound, [Ni(d-tG)<sub>3</sub>](NO<sub>3</sub>)<sub>2</sub>·2H<sub>2</sub>O, as green crystals. Despite the <1:3 Ni-ligand ratio used in the synthesis, the deoxy-thioguanosine binds to form three N<sup>7</sup>,S<sup>6</sup>-coordinated five-membered chelate rings with individual Ni<sup>II</sup> ions in mononuclear complexes rather than bridge metal centres into more extended oligomeric or polymeric structures.

Acta Crystallographica Section C Structural ChemistryVol. 81(3)
University Elmergib (LY), Newcastle University (GB)
Diamond Light Source
Openalex Percentile: Top 98%
Synthesis and Characterization of Heterocyclic Compounds
DOISourceOpenAlex
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Synthesis and crystal structure of a nickel(II) 2′-deoxy-6-thioguanosine nitrate complex — Andrew Houlton, Andrew R. Pike, et al. · Acta Crystallographica Section C Structural Chemistry (2025) | TGRS Research Map | TGRS