A rare case of granular cell tumor of gall bladder

Granular cell tumor is common over skin and subcutaneous and oral cavity. However, lesion is rare in biliary tract and ever more uncommon in gall bladder. These lesions are often misdiagnosed until proven by histology and immunohistochemistry where tumor is positive for CD 68, S 100 which points them toward neural origin of tumor. We report a case of 69-year-old male referred with a suspected gall bladder mass in Computed tomographic scan of abdomen. Laparotomy was done through Kocher's incision and extended cholecystectomy was performed. Histopathology and immunohistochemical study helped in determining gall bladder lesion to be granular cell tumor. Therefore, granular cell tumor can be considered a possible differential diagnosis of all the gall bladder lesion suspected of cholecystitis and carcinoma. Margin negative excision of the tumor is a curative approach for the patient.

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Publication Details

Journal
Journal of Surgical Case Reports
Published
2025-02-01
DOI
https://doi.org/10.1093/jscr/rjaf071
Primary Topic
Tumors and Oncological Cases
Type
article
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article

A rare case of granular cell tumor of gall bladder

Sunil Dhakal, Sapana Bhandari, Avinam H Kandangwa
Journal of Surgical Case Reports
Tumors and Oncological Cases
article

A rare case of granular cell tumor of gall bladder

Sunil Dhakal, Sapana Bhandari, Avinam H Kandangwa
article en

Abstract

Granular cell tumor is common over skin and subcutaneous and oral cavity. However, lesion is rare in biliary tract and ever more uncommon in gall bladder. These lesions are often misdiagnosed until proven by histology and immunohistochemistry where tumor is positive for CD 68, S 100 which points them toward neural origin of tumor. We report a case of 69-year-old male referred with a suspected gall bladder mass in Computed tomographic scan of abdomen. Laparotomy was done through Kocher's incision and extended cholecystectomy was performed. Histopathology and immunohistochemical study helped in determining gall bladder lesion to be granular cell tumor. Therefore, granular cell tumor can be considered a possible differential diagnosis of all the gall bladder lesion suspected of cholecystitis and carcinoma. Margin negative excision of the tumor is a curative approach for the patient.

Journal of Surgical Case ReportsVol. 2025(2)
B.P. Koirala Memorial Cancer Hospital (NP)
Good health and well-being
Openalex Percentile: Top 96%
Tumors and Oncological Cases
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