Synthesis of Oxadendralenes by Thermal Oxy‐Cope Type Rearrangement of Bis(α‐Hydroxyallenes)
Abstract We report the direct and selective synthesis of oxadendralenes starting from readily available bis(α‐hydroxyallenes). The designed sequence involves a hitherto unknown oxy‐Cope rearrangement of allenols by supplying a site for the migration of the 1,2‐diene moiety. Moreover, the so‐prepared oxadendralenes were converted into valuable polyfunctionalized scaffolds through effective late‐stage diversification.
Authors
- Teresa Martínez del Campo (ORCID: https://orcid.org/0000-0002-8729-4085)
- Pedro Almendros (ORCID: https://orcid.org/0000-0001-6564-2758)
- Daniel San Martín
Institutions
- Universidad Complutense de Madrid (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Instituto de Química Orgánica General (ES)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-02-19
- DOI
- https://doi.org/10.1002/adsc.202500080
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agencia Estatal de Investigación