Genomic Characterization and Antimicrobial Resistance of ESBL-Producing, Escherichia coli Isolates in Suzhou, China

Our findings highlighted the prevalence of globally circulating ESBL-producing <i>E. coli</i> clones, such as ST131 and ST1193, in Suzhou, China. These clones and sublineages are also resistant to quinolones. No predominant <i>bla</i>CTX-M subtypes were detected, while the coexistence of different ESBL types was strongly linked to resistance to amoxicillin/sulbactam, cefepime, ceftazidime, and aztreonam, suggesting the widespread circulation of diverse <i>bla</i>CTX-M genes within the Suzhou community. In clinical cases of ESBL resistance, carbapenem therapy is recommended as most (>90%) isolates were susceptible.