Circulating branched-chain amino acids and the risk of major adverse cardiovascular events in the UK biobank

Generally, higher levels of BCAAs, isoleucine, leucine, and valine were associated with an increased risk of MACE, except in participants older than 65. Additionally, in males, the lowest quintiles of leucine and valine were also associated with an increased risk of MACE.

Authors

Yongfu Yu (ORCID: https://orcid.org/0000-0003-4208-9480)
Bin Lu (ORCID: https://orcid.org/0000-0003-3720-7219)
Wanwan Sun (ORCID: https://orcid.org/0000-0003-2268-7715)
Ye Yao (ORCID: https://orcid.org/0000-0001-6240-9539)
Ruilang Lin
Yiming Li (ORCID: https://orcid.org/0000-0002-1828-8765)

Institutions

Fudan University (CN)
Huadong Hospital (CN)
Huashan Hospital (CN)

Publication Details

Journal: Frontiers in Endocrinology
Published: 2025-02-20
DOI: https://doi.org/10.3389/fendo.2025.1510910
Citations: 4
Primary Topic: Metabolomics and Mass Spectrometry Studies
Type: article
Field-Weighted Citation Impact: 3.22

Funders

National Natural Science Foundation of China
Huashan Hospital

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article

Circulating branched-chain amino acids and the risk of major adverse cardiovascular events in the UK biobank

Yongfu Yu, Bin Lu, Wanwan Sun, Ye Yao et al.

Feb 20, 2025

4 citations

Frontiers in Endocrinology

Metabolomics and Mass Spectrometry Studies

3.22

article

Circulating branched-chain amino acids and the risk of major adverse cardiovascular events in the UK biobank

Yongfu Yu, Bin Lu, Wanwan Sun, Ye Yao, Ruilang Lin, Yiming Li

February 20, 2025article en

4 citations

Abstract

Generally, higher levels of BCAAs, isoleucine, leucine, and valine were associated with an increased risk of MACE, except in participants older than 65. Additionally, in males, the lowest quintiles of leucine and valine were also associated with an increased risk of MACE.

Frontiers in EndocrinologyVol. 16

Fudan University (CN), Huadong Hospital (CN), Huashan Hospital (CN)

National Natural Science Foundation of China, Huashan Hospital

Openalex Percentile: Top 9%

Metabolomics and Mass Spectrometry Studies

3.22

DOI Open Access PDF OpenAlex

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Circulating branched-chain amino acids and the risk of major adverse cardiovascular events in the UK biobank — Yongfu Yu, Bin Lu, et al. · Frontiers in Endocrinology (2025) | TGRS Research Map | TGRS