Apolipoprotein E genotype is associated with island sign in lobar intracerebral hemorrhage
The <i>APOE</i> ε4 allele was associated with the island sign in lobar ICH patients. Our findings indicate that the presence of the island sign may be influenced by the underlying vasculopathy related to <i>APOE</i> ε4, which increases amyloid deposition in the cerebral vasculature.
Authors
- Dongsheng Fan (ORCID: https://orcid.org/0000-0002-3129-9821)
- Xinran Ma (ORCID: https://orcid.org/0000-0003-4968-6536)
- Danyang Tian (ORCID: https://orcid.org/0000-0002-4553-0115)
- Nan Li (ORCID: https://orcid.org/0000-0003-4231-8853)
- Wenzhi Wang (ORCID: https://orcid.org/0000-0002-0086-1121)
- Xiaolu Liu (ORCID: https://orcid.org/0000-0002-3060-3676)
- Qiong Yang (ORCID: https://orcid.org/0000-0002-9341-6763)
- Lu Tang (ORCID: https://orcid.org/0009-0006-0592-9179)
- Yong Chen (ORCID: https://orcid.org/0000-0002-3634-0328)
- Haixin Sun (ORCID: https://orcid.org/0000-0003-0766-8348)
- Xiao Huang
- Xin Huang (ORCID: https://orcid.org/0009-0005-5419-8969)
- Xiangzhu Zeng
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- National Health and Family Planning Commission (CN)
- Beijing Institute of Neurosurgery (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3389/fneur.2025.1540307
- Citations
- 2
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Natural Science Foundation of China
- Beijing Municipal Science and Technology Commission