METTL3-mediated methylation of RAC2 contributes to cell motility, oxidative stress and inflammation in TNF‐α-stimulated rheumatoid arthritis fibroblast-like synovial cells
The above results demonstrated that METTL3 facilitated the progression of RA via downregulating RAC2 in an m6A dependent mechanism in TNF-α-treated MH7A cells.
Authors
- Hua Ren (ORCID: https://orcid.org/0000-0001-8125-0674)
- Yifan Guo (ORCID: https://orcid.org/0000-0002-9700-5005)
- Yuejin Li (ORCID: https://orcid.org/0000-0003-1284-4668)
- Sanjiao Liu (ORCID: https://orcid.org/0009-0007-5941-889X)
- Zhen Xing Kong (ORCID: https://orcid.org/0000-0003-1961-1306)
- Mengyang Zhang (ORCID: https://orcid.org/0000-0002-2195-3973)
- Guohua Wei
Institutions
- Shanxi Medical University (CN)
- Shanxi University (CN)
- First Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s13018-025-05526-4
- Citations
- 8
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 7.49