RNA Interference Targeting Small Heat Shock Protein B8 Failed to Improve Distal Hereditary Motor Neuropathy in the Mouse Model
Given the limited beneficial effect of the treatment, the RNA interference-mediated reduction of HSPB8/Hspb8 expression might not be the best therapeutic strategy to treat dHMN/CMT2L, unless a higher viral load and earlier treatment can be applied to the mouse model.
Authors
- Vincent Timmerman (ORCID: https://orcid.org/0000-0002-2162-0933)
- Jasmien Orije (ORCID: https://orcid.org/0000-0002-6699-6221)
- István Katona (ORCID: https://orcid.org/0000-0002-0955-8911)
- Marleen Verhoye (ORCID: https://orcid.org/0000-0002-6267-0611)
- Joachim Weis (ORCID: https://orcid.org/0000-0003-3280-6773)
- Tatiana Da Silva Authier
- Bob Asselbergh (ORCID: https://orcid.org/0000-0003-2784-2470)
- Elias Adriaenssens (ORCID: https://orcid.org/0000-0001-9430-917X)
- Leen Vendredy (ORCID: https://orcid.org/0000-0002-7643-517X)
- Jonas Van Lent (ORCID: https://orcid.org/0009-0000-5339-6983)
- Vicky De Winter
Institutions
- Houston Methodist (US)
- University of Antwerp (BE)
- Universitätsklinikum Aachen (DE)
- VIB-UAntwerp Center for Molecular Neurology (BE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- The Journal of Gene Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jgm.70013
- Citations
- 1
- Primary Topic
- Hereditary Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- French Muscular Dystrophy Association
- Universiteit Antwerpen