Establishing the feasibility and reliability of broadband absorption spectroscopy for measuring cerebral water content in adults
Broadband absorption spectroscopy (BAS) has the potential to fill an unmet need for a non-invasive monitor of cerebral edema. In this work, we demonstrated the feasibility of BAS to measure water content in the adult human head by quantifying measurement reliability and the influence of ambient light on BAS-measured parameters. We observed strong inter-operator reliability of BAS-measurement of water (R<sup>2</sup> = 0.69, Lin's CCC = 0.78, p < 0.01). Similar significant reliability was observed for lipid (R<sup>2</sup> = 0.54), oxygen saturation (R<sup>2</sup> = 0.81), and total hemoglobin (R<sup>2</sup> = 0.44). Ambient light increased water content by approximately 2-3% compared to dark conditions.
Authors
- Rodrigo M. Forti (ORCID: https://orcid.org/0000-0002-8978-2525)
- Ofer Sadan (ORCID: https://orcid.org/0000-0002-0050-3025)
- Owen Samuels
- Prem Kandiah (ORCID: https://orcid.org/0000-0002-7964-0793)
- Shasha Bai (ORCID: https://orcid.org/0000-0003-4999-327X)
- Vidisha Goyal (ORCID: https://orcid.org/0000-0001-8065-5522)
- Feras Akbik (ORCID: https://orcid.org/0000-0002-1255-1622)
- Erin M. Buckley (ORCID: https://orcid.org/0000-0003-1068-8411)
- Michael D. Arrington
- L. H. Harris
Institutions
- Georgia Institute of Technology (US)
- Children's Hospital of Philadelphia (US)
- Emory University (US)
- Emory University Hospital (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- Biomedical Optics Express
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1364/boe.551192
- Citations
- 1
- Primary Topic
- Optical Imaging and Spectroscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Institute of Neurological Disorders and Stroke