Association of the Lipidome With Alzheimer's Disease and the Mediated Effect of Metabolites: A Two‐Step Mendelian Randomization Study
Our findings reveal the pathways through which PC (15:0_18:2) and PE (18:0_18:2) mediated the reduction of AD risk by lowering betaine levels.
Authors
- Xinyu Yang (ORCID: https://orcid.org/0000-0002-2194-4137)
- Juan Deng (ORCID: https://orcid.org/0009-0007-5963-0583)
- Yunfeng Yu (ORCID: https://orcid.org/0000-0002-7309-5608)
- Jingyi Wu (ORCID: https://orcid.org/0000-0002-5673-544X)
- Chenlu Guo (ORCID: https://orcid.org/0009-0001-6727-3391)
- Rong Yu (ORCID: https://orcid.org/0000-0002-7950-218X)
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- The Third Affiliated Hospital of Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/brb3.70352
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Hunan University
- Hunan University of Chinese Medicine